THE CHRYSALIN® BRAND THROMBIN PEPTIDE (TP508) TECHNOLOGY
Tissue repair and regeneration is a complex natural process that involves multiple types of cells and signaling molecules needed to restore function in damaged tissues and organs. In normal undamaged tissues these signals are shut off or used only for replacement of aging cells. This process must, however, be ready to quickly respond to acute tissue or vascular damage. To allow such responses to injury there are progenitor stem cells located throughout the body that bide their time waiting to be activated.
Nature has evolved elaborate systems to switch on these progenitor cells if the tissue becomes ischemic or when there is vascular damage. With vascular damage, thrombin is released to form blood clots and prevent blood loss. This happens every time we cut ourselves. We now know that a portion of this same thrombin molecule is released to initiate repair by activating endothelial progenitor cells and recruiting stem/progenitor cells to the damaged tissues. Over 30 years of research has contributed to our understanding of the thrombin receptor and cellular signals that initiate this regenerative process. Chrysalis BioTherapeutics is harnessing this natural process using specific thrombin peptides to switch on cellular responses to protect tissues and accelerate regeneration.
The Chrysalin® brand thrombin peptide, TP508 (rusalatide acetate), is a 23-amino-acid synthetic peptide is the natural amino acid sequence of the region of human thrombin (highlighted in gold) involved in activation of cell surface receptors on endothelial cells, inflammatory cells, and progenitor stem cells. TP508 stimulates repair and revascularization of multiple tissues and has anti-inflammatory and anti-apoptotic effects that contribute to its protective effects on cells and tissues.
TP508 binds to a subset of thrombin receptors that are expressed on the surface of specific cells involved in tissue repair. Upon binding to these receptors, TP508 activates signaling pathways that restore vascular function in endothelial cells and stimulate proliferation and mobilization of progenitor stem cells in vascular beds and tissues such as bone marrow, skin, brain, and intestinal mucosa. Activation of these cellular signaling pathways prevents the cells from dying after injury or exposure to radiation and initiates repair and regeneration.